Regimen Lab Skincare Encyclopedia ?


*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Resveratrol
INCI: Resveratrol
Source: Grapes
Resveratrol Molecule

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

Resveratrol is a polyphenol derived from red grapes and mulberries, and is one of the most potent antioxidants in skincare. What makes Resveratrol unique is its ability to activate Sirtuin and Splicing Factor Expression in skin cells, which is rather rare among antioxidants. What these mean for you: applying it on your skin can prevent your skin from “working too hard” and aging prematurely. It is an excellent choice of active for those looking for preventative skincare. A huge challenge when formulating with resveratrol is its solubility; high amounts of ethanol are usually required to solubilize it. Thankfully, we found a way to solubilize it without using ethanol. Look for it in combination with other antioxidants, especially those that can quench excited states of radical species.


  • Resveratrol has studied in concentrations of .25% - 1%, which is the range we recommend looking for in skincare products.
  • Note: there are different forms of resveratrol - look for trans-resveratrol - some skincare uses a mixture of cisresveratrol, which is not as effective.
  • No single antioxidant can tackle the whole UV damage/ inflammation / etc. process - so it's best to look for Resveratrol (like any antioxidant) in combination with other antioxidants

The full Regimen Lab Skincare Encyclopedia Entry for Resveratrol is in development. Check back in a few weeks for an update!

Resveratrol is a naturally occurring polyphenol, possessing two phenol rings linked to each other by an ethylene bridge. 


Resveratrol is present in large amounts in red grapes, nuts, pomegranate, and berries.

How it works?

Resveratrol antioxidant activity depends upon the arrangement of functional groups on nuclear structure. Therefore, configuration, substitution, and total hydroxyl groups number substantially influence several mechanisms of antioxidant activity, such as radical scavenging and metal ion chelation abilities. Previous studies showed that hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, but also the 3- and 5-OH groups. The study of antioxidant effect against hydroxyl (•OH) and hydroperoxyl (•OOH) radicals in aqueous simulated media using density functional quantum chemistry and computational kinetics methods revealed that trans-resveratrol may act as an efficient •OOH, and also presumably •OOR, radical scavenger.

Other benefits?

Resveratrol is able to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. It has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties.

Clinical trials - Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites. - Skin permeation and antioxidant efficacy of topically applied resveratrol -  in vitro and in vivo experiments. - Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol

The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.