Regimen Lab Skincare Encyclopedia ?


*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Resveratrol
INCI: Resveratrol
Source: Grapes
Resveratrol Molecule

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

Resveratrol is a polyphenol derived from red wine (grapes), and is one of the most potent known antioxidants. Signal transduction in inflammation. It's an ideal anti-aging active in skincare because it prevents oxidation in your skin and has been studied to boost skin firmness and decrease wrinkles even at low concentrations. But what makes resveratrol really interesting is it's 95% efficient in lipid peroxidation vs 65% in Vitamin E and 37% in Vitamin C. It's properties are similar to Silymarin, especially with respect to UV, modulation of signal transduction, and certiun activation (what we believe is the 'next big thing' in antiaging). In skincare, resveratrol is a strong choice those looking for strong antioxidants or anti-aging properties. Remember, like most great ingredients, its effects are not immediate and require at least a month of use to see benefit.


Resveratrol has studied in concentrations of .25% - 1%, which is the range we recommend looking for in skincare products. NOTE: there are different forms of resveratrol - look for transresveratrol - some skincare uses a mixture of cisresveratrol, which is not as effective. As with any antioxidant, no single antioxidant can tackle the whole UV damage/ inflammation / etc. process - so it's best to look for Resveratrol (like any antioxidant) in combination with other antioxidants


What is Resveratrol?

Resveratrol is a naturally occurring polyphenol, possessing two phenol rings linked to each other by an ethylene bridge. 


Resveratrol is present in large amounts in red grapes, nuts, pomegranate, and berries.

How it works?

Resveratrol antioxidant activity depends upon the arrangement of functional groups on nuclear structure. Therefore, configuration, substitution, and total hydroxyl groups number substantially influence several mechanisms of antioxidant activity, such as radical scavenging and metal ion chelation abilities. Previous studies showed that hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, but also the 3- and 5-OH groups. The study of antioxidant effect against hydroxyl (•OH) and hydroperoxyl (•OOH) radicals in aqueous simulated media using density functional quantum chemistry and computational kinetics methods revealed that trans-resveratrol may act as an efficient •OOH, and also presumably •OOR, radical scavenger.

Other benefits?

Resveratrol is able to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. It has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties.

Clinical trials - Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites. - Skin permeation and antioxidant efficacy of topically applied resveratrol -  in vitro and in vivo experiments. - Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol

The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.