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Lab Notes by regimen lab

Skincare ingredients that target redness

Redness in skincare is a common issue caused by factors like UV exposure, barrier damage, over-exfoliation, and genetics. While removing the root cause can help, redness-prone skin often requires a multi-faceted approach.

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Nov 25 2024

Comparison of Azelaic Advanced vs Finacea 15% Gel.

Utilizing the Differential Stripping method, our study revealed Azelaic Advanced delivers 65.4% of its active ingredient into the skin—nearly five times more than Finacea 15% Gel. This efficacy stems from its microemulsion design, featuring nanometer-sized droplets that optimize bioavailability. These findings underscore the power of formulation science in creating effective, consumer-friendly dermatological solutions.

Nov 21 2024

The Birth of Azelaic Advanced

Solubilizing azelaic acid seemed impossible—until a chance discovery changed everything. For years, we grappled with stubborn crystals, solubility issues, and delivery challenges, only to find the breakthrough in an unexpected experiment. In this Lab Note, we share the journey behind Azelaic Advanced, from navigating cutting-edge emulsions to creating a stable, clear serum that redefines what azelaic acid can do for skin. This is a story of persistence, curiosity, and turning the "impossible" into a game-changing innovation.

Nov 19 2024

Introducing Drops

Surprise! Drops are a new creation from Regimen Lab Research. We’ve taken cutting-edge ingredients (think: the next, next big things) and turned them into potent routine boosters.

Oct 18 2024

Skincare ingredients that target redness

Redness in skincare is a common issue caused by factors like UV exposure, barrier damage, over-exfoliation, and genetics. While removing the root cause can help, redness-prone skin often requires a multi-faceted approach. Key players in redness include Toll-like Receptor-2 (TLR-2), which triggers inflammation, and serine proteases, enzymes that overreact in sensitive skin, causing irritation. Other contributors like Protease-Activated Receptor-2 (PAR-2) and inflammatory cytokines also amplify redness. By using ingredients that target these pathways, you can reduce inflammation and calm redness for healthier, balanced skin.

Jul 05 2023

Arbutin converts to Hydroquinone in the skin???

Jun 12 2023

Can you mix Niacinamide and Ascorbic acid together?

This one is one of our top FAQs as there are quite a bit of misinformation regarding combining ingredients in skincare routines. We discuss whether or not Niacinamide and Ascorbic acid can be used together and if they can be formulated in one product.

Mar 30 2023

How did we make C.R.E.A.M. self-preserving?

This article explores the innovative approach of hurdle technology in skincare formulation, which involves using various factors such as pH adjustment, water activity reduction, chelation, good manufacturing practices, and anti-microbial ingredients to create a self-preserving skincare product. By harnessing the inherent anti-microbial properties of certain ingredients, formulators can create creams that are safe and effective without the need for traditional preservatives.

Mar 23 2023

Breaking Down the Science: A Comprehensive Comparison of Barrier Repair Products (BRPs)

Barrier repair products aim to restore and strengthen our skin's protective barrier, but with so many options on the market, it can be difficult to determine which one is right for you. In this blog, we'll compare the effectiveness of popular barrier repair products based on scientific evidence. From ceramide-rich creams to lipid-replenishing balms, we'll dive deep into each product to weed out the weaklings. 

Mar 22 2023

Peering into the Future: The Game-Changing Benefits of PPAR agonists in the skin

Unleash the potential of peroxisome proliferator-activated receptors (PPARs) for optimal skin health! These transcription factors play a critical role in regulating various cellular processes, including inflammation, differentiation, and proliferation, in skin cells. By modulating these pathways, PPARs can exert a significant impact on the skin's physiology and function, offering a plethora of benefits for skin barrier health. Discover the latest scientific findings on the mechanisms of PPARs in skin and explore the cutting-edge skincare ingredients that leverage their therapeutic potential. 

Mar 17 2023

Emulsifier Optimization

Do emulsifiers damage the barrier? Our studies showed that seemingly inert ingredients do have an influence on barrier repair even when formulated with the 3:1:1:1 lipid ratio!

Mar 16 2023

Fatty Acid Optimization

Do the types of fatty acids really matter in barrier repair? Our studies show every component in the 3:1:1:1 ratio matters!

Mar 08 2023

How to Know if a Product Actually Repairs the Barrier

In our barrier repair studies, C.R.E.A.M. 2.0 outperformed all of the products tested which comes as no surprise because this is what it was painstakingly designed to do.

We knew we wanted to improve on the barrier repair ability of our original C.R.E.A.M., so we kept formulating, updating, and testing until it surpassed all others in terms of barrier repair.      

Mar 01 2023

Why we updated C.R.E.A.M.?

Why did we decide to update C.R.E.A.M.? Why did we decide to add Petrolatum?

 

Oct 26 2021

Is 3:1:1:1 the best barrier lipid ratio?

3:1:1:1 is touted as the "golden ratio" in barrier repair but is it actually the best ratio to use in skincare?

Skincare Theory

Sep 13 2022

Antioxidants: The What, Why, and How?

We talk a lot about the important of antioxidants. In this lab note we explain exactly what they are, why they are important, and how they work in the skin.

Aug 26 2022

What Are Free Radicals and Why Should You Care?

Have you been hearing the term Free Radicals a lot in the skincare community and don't know what the fuss is about? Well, we're here to get you up to speed.

Aug 16 2022

The Science of Radiant Skin

Ever wonder what "the glow" is? Sometimes you see it in the morning, sometimes you don't. Radiant skin is like this mythical creature that appears only to those blessed by the skincare gods.

It appears out of the blue and disappears without a trace, not knowing when it will come back. However, it seems that the scientists here at Regimen Lab captured it and distilled it, until it revealed the Secret Science of Radiant skin. 

Author: Webster Magcalas
Reading time: 9 minutes
Level: Beginner

Note: No mythical creatures were harmed in the making of this article

Aug 08 2022

Is Wave 2.0 preservative-free?

Some of you noticed that there are no preservatives in the new Wave 2.0. Are the preservatives hidden somewhere? What kind of sorcery did we use to remove preservatives? The magic revealed within.

May 27 2022

Introducing Wave 2.0

Nerd out with us on how we developed Wave 2.0. Ready your coffee with extra shots as this will be a heck of a ride.

Mar 21 2022

Is Hyaluronic Acid all it's cracked up to be?

We just had to triple, quarduple, quintuple check that our previous results are correct about Hyaluronic acid.

Feb 04 2022

Introducing «Tidal Wave» Complex

Find out more on how we came up with the absolute beast of a hydrator: The Tidal Wave Complex.

Dec 22 2021

Ultimate Humectant Comparison

We stress tested out how humectants perform against each other. The result is the biggest surprise of the year.

Insider Guide

Nov 12 2021

Which Hydration Serum Reigns Supreme?

We tested the top Holy Grail Hydration Serums. This is the second greatest shock of our year.

How Skin Works

Oct 21 2021

A Play by Play on Barrier Repair

We keep talking about Barrier Repair all the time, but what exactly is it and how does it happen? Follow along so you know how to support it next time you damage your barrier.

Sep 22 2021

What happens when Ferulic acid gets oxidized?

As it turns out, oxidation isn't the end of Ferulic acid. The crazy part it, it might actually turn out better (shocked face)

Insider Guide

Aug 29 2021

Updates on Azelaic Acid, Retinoids and PHA Regulation

What's new with cosmetic regulations for Azelaic acid, Retinoids and PHA in Canada?

Skincare Blog

Apr 26 2021

Layering based on pH

pH is another important factor when considering layering of skincare. Dive in to learn how to tweak your regimen to get the healthiest skin and get the most out of your skincare.

Skincare Blog

Apr 15 2021

In Conclusion (Cautiously) use Occlusion

Occlusion is a double-edge sword. Discover more to learn how to avoid common pitfalls and how to maximize its effect in skincare.

Skincare Blog

Apr 15 2021

Number 1 Priority in Layering Skincare

There are a lot of factors that you need to consider when layering products. However, one factor in particular should be the utmost priority for everyone.

Insider Guide

Mar 24 2021

What makes an ingredient science-based?

How do you know if an ingredient is Science-based? How many journals should one read to say you know an ingredient? How do you assess the studies after reading them?

How Skin Works

Feb 17 2021

What we know about Humectants is outdated

We've been told multiple times that humectants are good for the skin because the hold water. However, the latest science disagrees.

Insider Guide

Feb 10 2021

Intro to Ingredient Pairings

Nutella and Banana, Pineapple and Pizza. Even in the skin, pairings can be a hit or miss. One thing is for sure, nothing beats the pair that kills Zombie cells.

Jan 29 2021

What is the Skin Barrier and why does it matter?

The term "Barrier" is now plastered all over the skincare industry. It has become the new buzzword in marketing. However, not everyone knows its meaning.

Jan 05 2021

The Beginner's Guide to (Evidence-Based) Skincare

Skincare can be overwhelming. With thousands of options, where do you start?  This guide helps you avoid costly mistakes when starting skincare.