Regimen Lab Skincare Encyclopedia ?
Epigallocatechin gallate (EGCG)
*Preliminary Lab Notes* - Full Entry Under Development
Ingredient Profile |
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| Common Name: Epigallocatechin gallate (EGCG) |
| INCI: Epigallocatechin gallate (EGCG) |
| Source: Green Tea |
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kligman ingredient evaluation |
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| Penetration: Under analysis |
| Biochemical Mechanism: Under analysis |
| Level of Evidence: Under analysis |
Regimen's Take
TLDR
Epigallocatechin gallate (EGCG)
https://pubchem.ncbi.nlm.nih.gov/compound/65064
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903211/ https://www.hindawi.com/journals/bmri/2017/5615647/
What is Epigallocatechin gallate?
Epigallocatechin-3-gallate (EGCG) is the major catechin, polyphenolic compound.
Source?
Green tea
How it works?
Inhibition of the erythema response evoked by UV radiation.
The phenol rings in EGCG structure act as electron traps and scavengers of free radicals, inhibit the formation of reactive oxygen species, and reduce the harm caused by oxidative stress.
EGCG inhibits the transfection of NF-B and AP-1 to downregulate the expression of iNOS and COX-2 mainly by scavenging NO, peroxynitrite, and other ROS/RNS and decreases the production of inflammatory factors to show the anti-inflammatory effects.
Other benefits?
Antioxidant and anti-inflammatory effects, cancer chemoprevention, protecting the skin from the damage caused by ionizing radiation, hydration, moisture retention, and wrinkle formation.
Clinical trials
https://www.ncbi.nlm.nih.gov/pubmed/8570723/ - Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols.
https://www.ncbi.nlm.nih.gov/pubmed/11209110 - Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796122/ - Skin Protective Effect of Epigallocatechin Gallate.
https://www.tandfonline.com/doi/full/10.1080/10717544.2016.1228718 - Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.
https://www.degruyter.com/downloadpdf/j/acph.2014.64.issue-2/acph-2014-0017/acph-2014-0017.pdf - In vivo human skin penetration of (–)-epigallocatechin-3-gallate from topical formulations.