Regimen Lab Skincare Encyclopedia ?

Epigallocatechin gallate (EGCG)

*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Epigallocatechin gallate (EGCG)
INCI: Epigallocatechin gallate (EGCG)
Source: Green Tea
Epigallocatechin Gallate (EGCG) Molecule

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

A polyphenol found in plants (e.g. grapeseed) and is of particular note as the compound responsible for many of the benefits found in green tea. In skincare, it has noted benefits an antioxidant preventing UV damage. It has also been shown to improve skin hydration, by regulating hyaluronic synthase, which is the skin's intrinsic means of producing hyaluronic acid. It has been well-studied to show anti-acne, anti-microbial properties in the skin. There is also emerging evidence of its anti-aging properties.

TLDR

• Studies have shown effective levels of EGCG at .5% - 1% but it may be effective at lower or higher levels • Don't confuse EGCG with Green Tea Extract! Extracts vary wildly in the concentration of actives, and many are found to include over 90% water. This is why pure compounds are strongly preferred in skincare.

Epigallocatechin gallate (EGCG)


    https://pubchem.ncbi.nlm.nih.gov/compound/65064

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903211/ https://www.hindawi.com/journals/bmri/2017/5615647/


    What is Epigallocatechin gallate?

    Epigallocatechin-3-gallate (EGCG) is the major catechin, polyphenolic compound.

    Source?

    Green tea


    How it works?

    Inhibition of the erythema response evoked by UV radiation.

    The phenol rings in EGCG structure act as electron traps and scavengers of free radicals, inhibit the formation of reactive oxygen species, and reduce the harm caused by oxidative stress.

    EGCG inhibits the transfection of NF-B and AP-1 to downregulate the expression of iNOS and COX-2 mainly by scavenging NO, peroxynitrite, and other ROS/RNS and decreases the production of inflammatory factors to show the anti-inflammatory effects.


    Other benefits?

    Antioxidant and anti-inflammatory effects, cancer chemoprevention, protecting the skin from the damage caused by ionizing radiation, hydration, moisture retention, and wrinkle formation.


    Clinical trials

    https://www.ncbi.nlm.nih.gov/pubmed/8570723/ - Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols.

    https://www.ncbi.nlm.nih.gov/pubmed/11209110 - Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796122/ - Skin Protective Effect of Epigallocatechin Gallate.

    https://www.tandfonline.com/doi/full/10.1080/10717544.2016.1228718 - Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.

    https://www.degruyter.com/downloadpdf/j/acph.2014.64.issue-2/acph-2014-0017/acph-2014-0017.pdf - In vivo human skin penetration of (–)-epigallocatechin-3-gallate from topical formulations.

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    The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.