Regimen Lab Skincare Encyclopedia ?

Dimethylmethoxy Chromanol

*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Dimethylmethoxy Chromanol
INCI: Dimethylmethoxy Chromanol
Source: Chemically Synthesized
Dimethylmethoxy Chromanol (DMC) Molecule

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

AKA Lipochroman-6 This is a bio-inspired molecule, not produced by the body, but engineered to be similar to gamma-tocopoherol. This results in a powerful antioxidant that results in protection from Radical Oxygen, Nitrogen, and Carbonal Species. Studies have shown DMC to have higher antioxidative power than many well-known antioxidants, like Vitamin C, Vitamin E, CoQ 10, Green Tea Extract, etc. In skincare, studies have shown it to have benefits on: wrinkle depth, skin elasticity, dark spots, and hyperpigmentation. Lipid peroxidation.

TLDR

Even tiny amounts of DMC can confer skin benefits, it has been proven to work in concentrations of .01 -.05% Fun fact: DMC's properties help protect formulations it is in from oxidazation.

Dimethylmethoxy Chromanol


https://pubchem.ncbi.nlm.nih.gov/compound/25254571


what it is, source, how it works (specific radical species it targets), other benefits, clinical trials with concentration, in vivo or in vitro tests, does it penetrate, scientific consensus on effectiveness,

https://patents.google.com/patent/EP2113242A1/en 


What is Dimethylmethoxy Chromanol?

Dimethylmethoxy chromanol is a potent antioxidant. (3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran)



Clinical trials

https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12039 - Singlet molecular oxygen quenching by the antioxidant dimethylmethoxy chromanol in solution and in ex vivo porcine skin.

https://www.sciencedirect.com/science/article/pii/S0928098717301604?via%3Dihub - Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage
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The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.

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