Regimen Lab Skincare Encyclopedia ?

Sodium Cocoyl Gluconate

Version 1.0 (last edited 10 Aug 2020)

Ingredient Profile

Common Name: Sodium Cocoyl Glutamate
INCI: Sodium Cocoyl Glutamate
Source: Sugar Beet, Corn, Wheat, Coconut
Sodium Cocoyl Glutamate has excellent cleansing properties while also being gentle.

kligman ingredient evaluation

Penetration: Cleanses sebum with minimal disruption on Ceramides, Cholesterol and Fatty Acids
Biochemical Mechanism: Creamy lather and excellent foam profile that leaves skin smooth and hydrated
Level of Evidence: Level C; Low Quality

Regimen's Take

We combined this with Sodium Cocoyl Glycinate and Cocamidopropyl Hydroxysultaine to produce a surfactant system that is heavy duty, has an excellent foam profile, without solubilizing barrier lipids. Although these surfactants seem to be gentle, it is important to have other ingredients that would lessen the penetration of surfactants. Look for glycerin high up in the ingredient list to ensure that there is minimal damage to the skin. 


  • Sodium Cocoyl Glutamate is a barrier friendly surfactant that cleanses the skin really well while leaving it super moist and supple.

What is Sodium Cocoyl Glutamate?


It is an amino acid-based surfactant that belongs to the acylglutamate group which is known to be one of the mildest and moisturizing groups of surfactants. The mildness of acylglutamates is owed to several functions:

  • Reduce the absorption of other surfactants like Sodium Lauryl Ether Sulfates
  • Soften hard water by removing minerals 
  • Carboxyl groups in the surfactant support the low pH of the skin
  • Degraded by enzymes (Odland bodies) in the skin into Glutamic Acid and Fatty Acids
  • Optimized proprietary blend with Sodium Cocoyl Glycinate and Cocamidopropyl Hydroxysultaine selectively solubilizes Squalane without solubilizing Intercellular Lipids


One of the common problems of surfactants is their potential to disrupt the organization of the intercellular cement lipids in the stratum corneum (i.e. ceramides, cholesterol, and fatty acids). Even the supposedly mildest Decyl Glucoside (Almost non-existent irritation in Zein Protein Dissolution, RBC test, Acute Eye Irritation Assay, HET-CAM)[^1] were shown to solubilize Cholesterol and Fatty acids.[^2] Acylglutamates are considered non-delipidants, as cholesterol and other intercellular cement lipids are not soluble in them. To test this, 5% of Sodium Cocoyl Glutamate was compared with 5% Cocamidopropyl Betaine, Sodium Lauryl Sulfate, Sodium Laureth Sulfate, and 5% of the proprietary blend. Sodium Cocoyl Glutamate, and the proprietary blend resulted in the least amount of solubilized intercellular lipids.[^3] This result is consistent with previous studies done to measure the amount of lipids extracted by surfactants. The results showed that acylglutamates have sufficient detergency to extract squalane but not barrier lipids such as cholesterol. In the same study, keratinocyte cytotoxicity was assessed and acylglutamates were superior in mildness with NR50 of 306 compared to 36 for acylmethyl taurate, 16.8 for sodium cocoyl isethionate, 9.9 for soap and 4.1 for SLS.[^4] In addition, the SC orderliness was also assessed by in-vitro ESR spin probe method showing that acylglutamates have an order parameter (S) of 0.73 compared to SLS 0.47, soap 0.65, water 0.89 (S=1 representing control).[^5] Another study showed that acylglutamates strip off NMF at negligible amounts compared to soap or other anionic surfactants.[^6] In congruence with the past studies, mobility and orientation of the intercellular lipids were tested and correlated with TEWL which gave further credence to the mildness of Sodium Cocoyl Glutamate.[^7] 


Although SCG is proven to be milder than most surfactants, entry to the skin is still possible. Hence, it is beneficial to use surfactants that degrade upon entry into the stratum corneum. Even though they are great non-delipidants, we believe that they would still have little to some disrupting effect on the stratum corneum lipids as they are still considered anionic surfactants. Thankfully, specialized organelles called Odland bodies that results from keratinization are extruded in the extracellular space for various functions including lipid processing. These organelles contain enzymes that are able to process Sodium Cocoyl Glutamate into Glutamic acid and various chain fatty acids. Glutamic acid resulting from the cleavage would serve as a base into the formation of various Natural Moisturizing Factors such as PCA. 


Compared to Sodium lauroyl glutamate, Sodium Cocoyl Glutamate is less irritating to the skin. Lauroyl is a C12 straight-chain similar to Cocoyl. The difference is that, although the major component of cocoyl is C12 (40%), the remaining components are actually longer alkyl chains. It is known that longer alkyl groups, particularly those that are branched or contain aromatic groups penetrate less compared to shorter alkyl groups.[^8] 


Glutamate based surfactants are also considered to be more bio-compatible as the major component of the stratum corneum is keratin, which is composed of alternating acidic and basic residues forming alpha-helical rods. This supports the observation that, although glutamates penetrate further into the skin compared to glycinates, their penetration results in less disruption of the keratin structures.[^9]


In theory, this makes sense, but as to whether enough Sodium Cocoyl Glutamate is processed by Odland bodies in the stratum corneum is yet to be elucidated. Although its irritation potential and selective solubilization, and the ability to disrupt the organized structure of intercellular layers have been tested, further studies involving in-vivo visualization of SC after SCG cleansing should be performed. One drawback of acylglutamate is the cost as it is deemed impractical due to cost.


[^1]: Mehling, A., Kleber, M., & Hensen, H. (2007). Comparative studies on the ocular and dermal irritation potential of surfactants. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 45(5), 747–758.

[^2]: Ananthapadmanabhan, K. P., Subramanyan, K., & Rattinger, G. B. (2002). Moisturizing cleansers. COSMETIC SCIENCE AND TECHNOLOGY SERIES, 405–432.

[^3]: Data will be shown in later article

[^4]: Sakamoto, K. (1997). Journal of Japanese Society of Cosmetic Science 21:125 

[^5]: Kawasaki, Y., Quan, D., Sakamoto, K., & Maibach, H. I. (1997).The Journal of Dermatology 194:238 

[^6]: Kawai, M., Imokawa, G., & Okamoto, A. (1989). Hihuka Shinnryou (Diagnostic Dermatology) 11:430 

[^7]: Kawasaki, Y. , Sakamoto, K., & Maibach, H. I. (1995). Journal of Society of Cosmetic Chemists Japan 29:252 

[^8]: Okasaka, M., Kubota, K., Yamasaki, E., Yang, J., & Takata, S. (2019). Evaluation of anionic surfactants effects on the skin barrier function based on skin permeability. Pharmaceutical Development and Technology, 24(1), 99–104.

[^9]: Fuchs, E. (1995). Keratins and the skin. Annual Review of Cell and Developmental Biology, 11, 123–153.


The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.



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