Regimen Lab Skincare Encyclopedia ?


*Preliminary Lab Notes* - Full Entry Under Development

Ingredient Profile

Common Name: Tetrahydrocurcuminoids
INCI: Tetrahydrocurcuminoids
Source: Turmeric

kligman ingredient evaluation

Penetration: Under analysis
Biochemical Mechanism: Under analysis
Level of Evidence: Under analysis

Regimen's Take

Derived from turmeric, long used in medicine, this is a phenolic compound that has a huge range of benefits to skin. It acts as an antioxidant with free-radical fighting properties. It also has anti-inflammatory properties, by way of ____. Tetrahydrocurcuminoids is also a tyrosinase inhibitor (like AA, etc.) and thus has anti-hyperpigmentation properties. Tetrahydrocurcuminoids also help prevent secretion of MMPs (MMPs degrade collgan, etc.) Tetrahydrocurcuminoids are also implicated in acne-fighting. Skin is a jungle of bacteria, mostly beneficial flora. Sometimes, bacteria talk to each other (WTF!) and create biofilms. This communication happens through - phenolic compounds are known to inhibit this corum sensing, preventing bacteria from turning into acne and other biofilms, infections.


Tetrahydrocurcuminoids need to be in a slightly acidic formula (ph 5.5-6.5). Since it's a phenolic compound, you should find chelators (EDTA, BHT) to ensure Tetrahydrocurcuminoids stay active (else it can be rendered inert and you're wasting your money!)
The Skincare Encyclopedia aims to improve public understanding of the biology and chemistry of skincare. The Encyclopedia is rooted in core scientific principles and extensive research, in many cases in collaboration with the authors of the original studies referenced. This is a project of Regimen Lab, maintained by a group of multidisciplinary scientists, MDs, and researchers.