The full Regimen Lab Skincare Encyclopedia Entry for Glyceryl Glucoside is in development. Check back in a few weeks for an update!
What is Glyceryl Glucoside?
Glyceryl Glucoside is a natural combination of glycerol and glucose and is becoming the new molecule for next generation moisturizing ingredients. It is naturally present in red, rosé and white wine, as well as in Japanese food brewed with koji, like sake, miso and mirin (1). Recently, many scientific reports suggested the key role of glyceryl glucoside in induction of aquaporin-3 protein, which is an essential protein in water molecule transport across the skin cell membrane.
What are its benefits on the skin?
In skin, glyceryl glucoside treatment enhanced glycerol derivatives and increased the aquaporin-3 expression in vitro and ex vivo (2). Glyceryl glucosides are mentioned for increasing skin elasticity, moisturizing, the reduction of symptoms like itching, burning, tightness, tingling, and feeling of dryness (3).
The moisturization and barrier‐strengthening benefits of moisturizing formulations containing glyceryl‐glucoside, urea and other components of the Natural Moisturizing Factor were also investigated (3). Vehicle‐controlled studies confirmed the additive benefits of these agents, underscoring the efficacy of addressing the deficiencies of xerotic skin conditions with topical formulations crafted with key ingredients that address the multiple factors in xerosis.
1 Takenaka F, Uchiyama H, Synthesis of alpha-D-glucosylglycerol by alpha-glucosidase and some of its characteristics, Biosci Biotechnol Biochem. 64(9):1821-6, 2000.
2 Schrader A, Siefken W, Kueper T, Breitenbach U, Gatermann C, Sperling G, Biernoth T, Scherner C, Stäb F, Wenck H, Wittern KP, Blatt T., Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin, Skin Pharmacol Physiol. 25(4):192-9, 2012.
3 Weber TM, Kausch M, Rippke F, Schoerlermann AM, Filbry A (2012) Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide. J Clin Aesthet Dermatol, 29–39.