Lab Notes - The Regimen Lab Skincare Blog ?

Ellagic acid

What is Ellagic Acid ?

Ellagic acid is one of the antioxidant components of ginger that has been studied for various properties in both mice and humans. Ancient experiments on eastern medicine noted that roasted ginger is better in alleviating various symptoms. Interestingly, it was found that fresh ginger contains high amounts of a compound called Gingerone, which converts to Zingerone on drying or cooking. Gingerone and Zingerone both share the same structure with Curcumin (the active ingredient in Turmeric), giving them similar pharmacologic effects. Acetyl Zingerone has an added acetyl group (methyl group single-bonded to a carbonyl), which confers additional scavenging, chelating, and stabilizing potential to Zingerone. AZ is intentionally engineered to neutralize key Radical Oxygen species (ROS), Non-radical Oxygen species (singlet oxygen), and strong nucleophiles (peroxynitrite) that are induced by UVR. It is reported to have the following properties:

Acts as a multi-target antioxidant
Minimizes lipid, protein and DNA damage
Tones down the inflammatory response
Boosts the Extracellular Matrix to prevent colalgen degradation
Clinically proven to improve signs of photoaging

Does it Penetrate ?

There are currently no studies on skin penetration of AZ. Because it is relatively small and lipophilic, it is more than likely to penetrate the skin. Since its action is mostly to scavenge and quench free radicals, its presence on the upper layers alone is beneficial. The pharmacodynamics of Zingerone were previously studied, and it showed excellent tissue distribution and good blood-brain barrier penetrance.[4]

How does it work?

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Clinical Trials

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